Fresh analysis indicates that patients who come off new slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who stop traditional lifestyle regimens.
Findings released in a leading health publication points out that while overweight people can lose a large proportion of their total mass while using the jabs, the mass is regained at an estimated rate of nearly a kilo each month upon discontinuation.
"People buying such medications should be informed of the danger of quick weight regain when the medication ends," stated lead investigator Dr. Susan Jebb.
Such speed of regain suggests a return to starting weight within about 18 months.
Weighing Approaches
The analysis, which looked at 37 of trials involving over 9,000 of participants, compared the results of GLP-1 agonists with other pills.
Scientists note that individuals who shed pounds through diet and exercise typically experience a slower weight regain—approximately 0.1 kg a month—post-intervention.
Understanding the Rapid Rebound
Experts suggest the mode of action of the jabs accounts for the accelerated regain.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which helps regulate appetite.
"Sustained high doses of the hormone concentrations several times higher than normal could lead to the body to generate a reduced amount of its endogenous hormone, and could diminish sensitivity to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this GLP-1 'fix' means appetite is unsuppressed, making overeating far more likely."
A Lifelong Disease?
Health authorities suggest the injections for people with obesity-related medical conditions, alongside recommended diet and exercise modifications.
Professionals argue that, considering the high risk of weight regain, the therapy should be considered long-term.
This view is supported by drug manufacturers, who say that the findings "emphasize the persistent character of obesity," similar to managing diseases like diabetes.
Patient Experiences
Users who have discontinued the jabs report a powerful resurgence of cravings.
"I experienced a switch that goes on and you're instantly extremely hungry," said an individual.
This challenge is exacerbated if users have not adopted permanent lifestyle or habit changes during therapy.
Widespread Use
Figures show that millions of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Use is more common among women compared to men.
- The 40s and 50s age group shows the highest usage rates.
- Many access the drugs through private healthcare rather than the NHS.
In conclusion, researchers stress that while the jabs are potent tools for weight loss, they are not a permanent cure and maintained weight loss likely depends on combined behavioural support.
